Festkolloquium der Abteilung 8
Medizinphysik und metrologische Informationstechnik
anlässlich der Verabschiedung von Herrn Dr. Martin Burghoff
Freitag, 20. April 2018, 14.00 Uhr
Prof. Dr. med. Gabriel Curio
Klinik für Neurologie mit experimenteller Neurologie, Charité Berlin
Berlin Bernstein Center for Computational Neuroscience
Non-invasive detection of human cerebral population spikes in MEG and EEG
The capability to detect spikes defines a striking contrast between invasive (microscopic) and non-invasive (macroscopic) recordings. While the latter are dominated by summed postsynaptic potentials reflecting neuronal input, invasive electrodes can provide direct access also to the very output of neuronal computation – spikes. This micro/macro gap, however, has been narrowed gradually over the last years by combining special physiological paradigms with neurotechnological advances. Surveying this research agenda on spike-related high-frequency MEG/EEG the tripartite lecture will (i) address the basic neurophysics of near-field and far-field signals distinguishing slow from fast neuronal activities, (ii) elaborate on high-frequency (> 600 Hz) somatosensory evoked burst responses serving as a key paradigm to establish the feasibility of non-invasive spike-related recordings, and (iii) report on novel neurotechnology enabling high-resolution mappings of EEG activities even above 1 kHz which reflect non-invasive correlates of human neocortical multi-unit (‘population’) spike responses. Critically, if recording conditions provide optimal SNR, event detection of even single-trial (i.e., unaveraged) 600 Hz bursts becomes feasible, offering a unique perspective to study the immediate impact of cognitive processes on the generation of human cortical population spikes.
Physikalisch-Technische Bundesanstalt – Institut Berlin
Abbestraße 2-12, 10587 Berlin
Zu diesem Kolloquium sind alle Interessenten herzlich eingeladen!