For publications (including conference contributions), please refer to BIOQIC in your acknowledgements:

xxx gratefully acknowledges funding from the German Research Foundation (GRK2260, BIOQIC)

Please send all accepted papers and conference presentations to:

Forschungsförderung – BIOQIC – Neue Generation von Bildgebungsspezialisten

Ingolf Sack

Fortschr Röntgenstr 2017; 188(01): 86




Felix Schrank, Carsten Warmuth, Heiko Tzschätzsch, Bernhard Kreft, Sebastian Hirsch, Jürgen Braun, Thomas Elgeti, Ingolf Sack. Journal of Cerebral Blood Flow and Metabolism, 2019, online.

Yolanda Prezado, Gregory Jouvion, Consuelo Guardiola, Wilfredo Gonzalez, Marjorie Juchaux, Judith Bergs, Catherine Nauraye, Dalila Labiod, Ludovic De Marzi, Frederic Pouzoulet, Annalisa Patriarca, Remi Dendale. Int J Radiat Oncol Biol Phys. 2019; 104(2): 266-271.

Steffen Lukas, Sarah Feger, Matthias Rief, Elke Zimmermann, Marc Dewey. European Radiolog, 2019, accepted for publication.

Niklas Heucke, Tilo Wuensch, Julia Mohr, Magnus Kaffarnik, Ruza Arsenic, Bruno Sinn,Tobias Müller, Johann Pratschke, Martin Stockmann, Ingolf Sack and Heiko Tzschätzsch. Journal of Gastroenterology and Hepatology, 2019, in press.

Angela Ariza de Schellenberger, Heiko Tzschätzsch, Baptiste Polchlopek, Gergely Bertalan, Felix Schrank, Karolina Garczynska, Paul A. Janmey, Jürgen Braun, Ingolf Sack. Journal of Biomechanics 2019; 88, 201-208.

Shuangqing Wang, Bernhard Hesse, Marco Roman, Deborah Stier, Hiram Castillo-Michel, Marine Cotte, Jussi-Petteri Suuronen, Adrien Lagrange, Helena Radbruch, Friedemann Paul, Matthias Taupitz, Eyk Schellenberger, Ingolf Sack, and Carmen Infante-Duarte. Investigative Radiology 201, in press.

Leili Riazy, Tobias Schaeffter, Marc Olbrich, Johannes Schueler, Florian von Knobelsdorff‐Brenkenhoff, Thoralf Niendorf, Jeanette Schulz‐Menger. Magn Reson Med 2019; 1–11.

Clarissa Wink, Giulio Ferrazzi, Jean Pierre Bassenge, Sebastian Flassbeck, Simon Schmidt, Tobias Schaeffter, Sebastian Schmitter. Magn Reson Med 2019;1–15.

Frank Sauer, Linda Oswald, Angela Ariza de SchellenbergerHeiko Tzschätzsch, Felix Schrank, Tony Fischer, Jürgen Braun, Claudia Tanja Mierke, Rustem Valiullin, Ingolf Sack and Josef Alfons Käs. The Royal Society of Chemistry. SoftMatter 2019; 15: 3055-3064.



Heiko Tzschätzsch, Bernhard Kreft, Felix Schrank, Judith Bergs, Jürgen Braun, and Ingolf Sack. Sci Rep 2018; 18(1): 17888.

Gergely Bertalan, Jing Guo, Heiko Tzschätzsch, Charlotte Klein, Eric Barnhill, Ingolf Sack, Jürgen Braun. Magn Reson Med 2018; 1–12.

Consuelo Guardiola, Yolanda Prezado, Christophe Roulin, Judith Bergs. Clin Transl Rad Oncol 2018; 13: 7-13.

Matteo Ippoliti, Lisa Adams, Winfried Brenner, Bernd Hamm, Pascal Spincemaille, Yi Wang, Marcus Makowski. J Magn Reson Imaging 2018; 48: 1410–1420.




BIOQIC book “Quantification of Biophysical Parameters in Medical Imaging” available online now! – or on Amazon


The eBook can be downloaded here and  is suitable for most mobile reading devices.

The book, edited by Ingolf Sack and Tobias Schaeffter, provides a selection of essential knowledge on the image-based quantification of biophysical parameters for the purpose of clinical diagnosis. The authors regard clinical imaging scanners as physical measurement systems capable of quantifying intrinsic parameters for depiction of the constitution and biophysical properties of in vivo tissue. On the one hand, this approach supports the development of new methods of imaging highly reproducible, system-independent, and quantitative biomarkers, and these methods receive detailed attention in the book. On the other hand, the reader will also gain a deeper understanding of how physical tissue properties interact with the generation of signals in medical imaging, opening new windows on the intricate and fascinating relationship between the structure and function of living tissues. The book will be of interest to all who recognize the limitations of basing clinical diagnosis primarily on visual inspection of images and who wish to learn more about the diagnostic potential of quantitative and biophysics-based medical imaging markers and the challenges that the paucity of such markers poses for next-generation imaging technologies.



1 Introduction: Medical Imaging for the Quantitative Measurement of Biophysical Parameters – Ingolf Sack and Tobias Schaeffter

Part I Biological and Physical Fundamentals

2 The Fundamentals of Transport in Living Tissues Quantified by Medical Imaging Technologies – Sebastian Hirsch, Tobias Schaeffter, and Ingolf Sack

3 Mathematical Modeling of Blood Flow in the Cardiovascular System – Alfonso Caiazzo and Irene E. Vignon-Clementel

4 A Biphasic Poroelasticity Model for Soft Tissue – Sebastian Hirsch

5 Physical Properties of Single Cells and Collective Behavior – Hans Kubitschke, Erik W. Morawetz, Josef A. Käs, and Jörg Schnauß

6 The Extracellular Matrix as a Target for Biophysical and Molecular Magnetic Resonance Imaging – Angela Ariza de Schellenberger, Judith Bergs, Ingolf Sack, and Matthias Taupitz

Part II Medical Imaging Technologies

7 Mathematical Methods in Medical Image Processing – Gitta Kutyniok, Jackie Ma, and Maximilian März

8 Acceleration Strategies for Data Sampling in MRI – Christoph Kolbitsch and Tobias Schaeffter

9 4D Flow MRI – Sebastian Schmitter and Susanne Schnell

10 CEST MRI – Martin Kunth and Leif Schröder

11 Innovative PET and SPECT Tracers – Ulrich Abram

12 Methods and Approaches in Ultrasound Elastography – Heiko Tzschätzsch

13 Photoacoustic Imaging: Principles and Applications – Jan Laufer

14 Fundamentals of X-Ray Computed Tomography: Acquisition and Reconstruction – Marc Dewey and Marc Kachelrieß

Part III Applications

15 Quantification of Myocardial Effective Transverse Relaxation Time with Magnetic Resonance at 7.0 Tesla for a Better Understanding of Myocardial (Patho)physiology – Till Huelnhagen, Teresa Serradas-Duarte, Fabian Hezel, Katharina Paul, and Thoralf Niendorf

16 Extracellular Matrix-Specific Molecular MR Imaging Probes for the Assessment of Aortic Aneurysms – Julia Brangsch, Carolin Reimann, and Marcus R. Makowski

17 Diffusion-Based MRI: Imaging Basics and Clinical Applications – Michael Scheel

18 Quantification of Functional Heterogeneities in Tumors by PET Imaging – Winfried Brenner, Florian Wedel, and Janet F. Eary

19 Tumor Characterization by Ultrasound Elastography and Contrast-Enhanced Ultrasound – Thomas Fischer, Anke Thomas, and Dirk-André Clevert

20 Sensitivity of Tissue Shear Stiffness to Pressure and Perfusion in Health and Disease – Jing Guo, Florian Dittmann, and Jürgen Braun

21 Radionuclide Imaging of Cerebral Blood Flow – Ralph Buchert

22 Cardiac Perfusion MRI – Amedeo Chiribiri

23 Myocardial Perfusion Assessment by 3D and 4D Computed Tomography – Marc Dewey and Marc Kachelrieß