For publications (including conference contributions), please refer to BIOQIC in your acknowledgements:

xxx gratefully acknowledges funding from the German Research Foundation (GRK2260, BIOQIC)

Please send all accepted papers and conference presentations to:




  • Mura J, Schrank F, Sack I

An analytical solution to the dispersion-by-inversion problem in magnetic resonance elastography

Magn Reson Med. 2020


  • Kofler A, Dewey M, Schaeffter T, Wald C, Kolbitsch C

Spatio-Temporal Deep Learning-Based Undersampling Artefact Reduction for 2D Radial Cine MRI With Limited Training Data



  • Kreft B, Tzschätzsch H, Schrank F, Bergs J, Streitberger KJ, Wäldchen S, Hetzer S, Braun J, Sack I

Time-Resolved Response of Cerebral Stiffness to Hypercapnia in Humans

Ultrasound Med Biol 2020


  • Ovtchinnikov E, Brown R, Kolbitsch C,  Pasca E, Costa-Luis C, Gillman AG, Thomas BA, Efthimiou N, Mayer J, Wadhwa P, Ehrhardt MJ, Ellis S, Jørgensen JS, Matthews J, Prieto C, Reader AJ, Tsoumpas C, Turner M, Atkinson D, Thielemans K

SIRF: Synergistic Image Reconstruction Framework

Computer Physics Communications 2020


  • Burkhardt C, Tzschätzsch H, Schmuck R, Bahra M, Jürgensen C, Pelzer U, Hamm B, Braun J, Sack I, Marticorena Garcia SR

Ultrasound Time-Harmonic Elastography of the Pancreas: Reference Values and Clinical Feasibility

Invest Radiol 2020


  • Wang S, Millward JM, Hanke-Vela L, Malla B, Pilch K, Gil-Infante A, Waiczies S, Mueller S, Boehm-Sturm P, Guo J, Sack I, Infante-Duarte C

MR Elastography-Based Assessment of Matrix Remodeling at Lesion Sites Associated Clinical Severity in a Model of Multiple Sclerosis

Front Neurol 2020




  • Schaafs LA, Tzschätzsch H, Steffen IG, Braun J, Hamm B, Sack I, Elgeti T

Quantification of Aortic Stiffness by Ultrasound Time-Harmonic Elastography: The Effect of Intravascular Pressure on Elasticity Measures in a Porcine Model

Invest Radiol 2019


  • Chae W, Niesel K, Schulz M, Klemm F, Joyce J, Prümmer M, Brill B, Bergs J, Rödel F, Pilatus U, Sevenich L

Evaluating Magnetic Resonance Spectroscopy as a Tool for Monitoring Therapeutic Response of Whole Brain Radiotherapy in a Mouse Model for Breast-to-Brain Metastasis

Front Oncol 2019


  • Streitberger K*, Lilaj L*, Schrank F, Braun J, Hoffmann K, Reiss-Zimmermann M, Käs J, Sack I

*Both authors contributed equally to this manuscript

How tissue fluidity influences brain tumor progression

Proceedings of the National Academy of Sciences 2019


  • Shahryari M, Tzschätzsch H, Guo J, Rodrigo Marticorena Garcia S, Böning G, Fehrenbach U, Stencel L, Asbach P, Hamm B, Käs JA, Braun J, Denecke T, Sack I

Tomoelastography distinguishes non-invasively between benign and malignant liver lesions

Cancer Research 2019


  • Bertalan G, Klein C, Schreyer S, Steiner B, Kreft B, Tzschätzsch H, Ariza de Schellenberger A, Braun J, Guo J, Sack

Biomechanical properties of the hypoxic and dying brain quantified by magnetic resonance elastography

Acta Biomaterialia 2019
  • Schrank F, Warmuth C, Görner S, Meyer T, Tzschätzsch H, Guo J, Oguz Uca Y, Elgeti T, Braun J, Sack I

Real-time magnetic resonance elastography for viscoelasticity quantification in skeletal muscle during dynamic exercises

Magnetic Resonance in Medicine 2019


  • Becker KM, Blaszczyk E, Funk S, Nuesslein A, Schulz-Menger J, Schaeffter T, Kolbitsch C

Fast myocardial T1 mapping using cardiac motion correction

Magn Reson Med 2019


  • Becker KM, Schulz-Menger J, Schaeffter T, Kolbitsch C

Simultaneous high-resolution cardiac T1 mapping and cine imaging using model-based iterative image reconstruction

Magn Reson Med 2019


  • Hetzer S, Hirsch S, Braun J, Sack I, Weygandt M

Viscoelasticity of striatal brain areas reflects variations in body mass index of lean to overweight male adults

Brain Imaging and Behavior 2019


  • Aldoj N, Lukas S, Dewey M, Penzkofer T

Semi-automatic classification of prostate cancer on multi-parametric MR imaging using a multi-channel 3D convolutional neural network

European Radiology 2019


  • Guo J, Bertalan G, Meierhofer D, Klein C, Schreyer S, Steiner B, Wang S, Vieira da Silva R, Infante-Duarte C, Koch S, Boehm-Sturm P, Braun J, Sack I

Brain maturation is associated with increasing tissue stiffness and decreasing tissue fluidity

Acta Biomater 2019


  • Marticorena Garcia S, Hamm B, Sack I

Tomoelastography for non-invasive detection and treatment monitoring in acute appendicitis

BMJ Case Rep 2019


  • Ippoliti M, Lukas M, Brenner W, Schaeffter T, Makowski MR, Kolbitsch C

3D nonrigid motion correction for quantitative assessment of hepatic lesions in DCE‐MRI

Magnetic Resonance in Medicine 2019


  • Schaafs L, Tzschätzsch H, Reshetnik A, van der Giet M, Braun J, Hamm B, Sack I, Elgeti T

Ultrasound Time-Harmonic Elastography of the Aorta – Effect of Age and Hypertension on Aortic Stiffness

Investigative Radiology 2019


  • Kofler A, Dewey M, Schaeffter T, Wald C, Kolbitsch C

Spatio-Temporal Deep Learning-Based Undersampling Artefact Reduction for 2D Radial Cine MRI with Limited Data

IEEE Transactions on Medical Imaging 2019


  • Grossmann M, Tzschätzsch H, Lang ST, Guo J, Bruns A, Dürr M, Hoyer BF, Grittner U, Lerchbaumer M, Nguyen Trong M, Schultz M, Hamm B, Braun J, Sack I, Marticorena Garcia SR

US Time-Harmonic Elastography for the Early Detection of Glomerulonephritis

Radiology 2019


  • Lang ST, Guo J, Bruns A, Dürr M, Braun J, Hamm B, Sack I, Marticorena Garcia SR

Multiparametric Quantitative MRI for the Detection of IgA Nephropathy Using Tomoelastography, DWI, and BOLD Imaging

Investigative Radiology 2019


  • Bertalan G, Boehm-Sturm P, Schreyer S, Morr AS, Steiner B, Tzschätzsch H, Braun J, Guo J, Sack I

The influence of body temperature on tissue stiffness, blood perfusion, and water diffusion in the mouse brain

Acta Biomaterialia 2019


  • Macdonald J, Wäldchen S, Hauch S, Kutyniok G

A Rate-Distortion Framework for Explaining Neural Network Decisions


  • Wäldchen S, Macdonald J, Hauch S, Kutyniok G

The Computational Complexity of Understanding Network Decisions


  • Schrank F, Warmuth C, Tzschätzsch H, Kreft B, Hirsch S, Braun J, Elgeti T, Sack I

Cardiac-gated steady-state multifrequency magnetic resonance elastography of the brain: effect of cerebral arterial pulsation on brain viscoelasticity

Journal of Cerebral Blood Flow and Metabolism 2019


  • Prezado Y, Jouvion G, Guardiola C, Gonzalez W, Juchaux M, Bergs J, Nauraye C, Labiod D, De Marzi L, Pouzoulet F, Patriarca A, Dendale R

Tumor Control in RG2 Glioma-Bearing Rats: A Comparison Between Proton Minibeam Therapy and Standard Proton Therapy

Int J Radiat Oncol Biol Phys 2019


  • Lukas S, Feger S, Rief M, Zimmermann E, Dewey M

Noise reduction and motion elimination in low-dose 4D myocardial computed tomography perfusion (CTP): preliminary clinical evaluation of the ASTRA4D algorithm

European Radiology 2019


  • Heucke N, Wuensch N, Mohr J, Kaffarnik M, Arsenic R, Sinn B, Müller T, Pratschke J, Stockmann M, Sack I, Tzschätzsch H

Non-invasive structure–function assessment of the liver by 2D time-harmonic elastography and the dynamic Liver MAximum capacity (LiMAx) test

Journal of Gastroenterology and Hepatology 2019


  • Ariza de Schellenberger A, Tzschätzsch H, Polchlopek B, Bertalan G, Schrank F, Garczynska K, Janmey PA, Braun J, Sack I

Sensitivity of multifrequency magnetic resonance elastography and diffusion-weighted imaging to cellular and stromal integrity of liver tissue

Journal of Biomechanics 2019


  • Wang S, Hesse B, Roman M, Stier D, Castillo-Michel H, Cotte M, Suuronen J, Lagrange A, Radbruch H, Paul F, Taupitz M, Schellenberger E, Sack I, Infante-Duarte C

Increased Retention of Gadolinium in the Inflamed Brain After Repeated Administration of Gadopentetate Dimeglumine

Investigative Radiology 2019


  • Riazy L, Schaeffter T, Olbrich M, Schueler J, von Knobelsdorff‐Brenkenhoff F, Niendorf T, Schulz‐Menger J

Porous medium 3D flow simulation of contrast media washout in cardiac MRI reflects myocardial injury

Magn Reson Med 2019


  • Wink C, Ferrazzi G, Bassenge JP, Flassbeck S, Schmidt S, Schaeffter T, Schmitter S

4D flow imaging with 2D‐selective excitation

Magn Reson Med 2019


  • Sauer F, Oswald L, Ariza de Schellenberger A, Tzschätzsch H, Schrank F, Fischer T, Braun J, Mierke CT, Valiullin R, Sack I, Käs JA

Collagen networks determine viscoelastic properties of connective tissues yet do not hinder diffusion of the aqueous solvent

The Royal Society of Chemistry. SoftMatter 2019




  • Tzschätzsch H, Kreft B, Schrank F, Bergs J, Braun J, Sack I

In vivo time-harmonic ultrasound elastography of the human brain detects acute cerebral stiffness changes induced by intracranial pressure variations

Sci Rep 2018


  • Bertalan G, Guo J, Tzschätzsch H, Klein C, Barnhill E, Sack I, Braun J

 Fast tomoelastography of the mouse brain by multifrequency single‐shot MR elastography

 Magn Reson Med 2018


  • Guardiola C, Prezado Y, Roulin C, Bergs J

Effect of X-ray minibeam radiation therapy on clonogenic survival of glioma cells

Clin Transl Rad Oncol 2018


  • Ippoliti M, Adams L, Brenner W, Hamm B, Spincemaille P, Wang Y, Makowski M

Quantitative susceptibility mapping across two clinical field strengths: Contrast‐to‐noise ratio enhancement at 1.5T

J Magn Reson Imaging 2018





BIOQIC book “Quantification of Biophysical Parameters in Medical Imaging” available online now! – or on Amazon


The eBook can be downloaded here and  is suitable for most mobile reading devices.

The book, edited by Ingolf Sack and Tobias Schaeffter, provides a selection of essential knowledge on the image-based quantification of biophysical parameters for the purpose of clinical diagnosis. The authors regard clinical imaging scanners as physical measurement systems capable of quantifying intrinsic parameters for depiction of the constitution and biophysical properties of in vivo tissue. On the one hand, this approach supports the development of new methods of imaging highly reproducible, system-independent, and quantitative biomarkers, and these methods receive detailed attention in the book. On the other hand, the reader will also gain a deeper understanding of how physical tissue properties interact with the generation of signals in medical imaging, opening new windows on the intricate and fascinating relationship between the structure and function of living tissues. The book will be of interest to all who recognize the limitations of basing clinical diagnosis primarily on visual inspection of images and who wish to learn more about the diagnostic potential of quantitative and biophysics-based medical imaging markers and the challenges that the paucity of such markers poses for next-generation imaging technologies.



1 Introduction: Medical Imaging for the Quantitative Measurement of Biophysical Parameters – Ingolf Sack and Tobias Schaeffter

Part I Biological and Physical Fundamentals

2 The Fundamentals of Transport in Living Tissues Quantified by Medical Imaging Technologies – Sebastian Hirsch, Tobias Schaeffter, and Ingolf Sack

3 Mathematical Modeling of Blood Flow in the Cardiovascular System – Alfonso Caiazzo and Irene E. Vignon-Clementel

4 A Biphasic Poroelasticity Model for Soft Tissue – Sebastian Hirsch

5 Physical Properties of Single Cells and Collective Behavior – Hans Kubitschke, Erik W. Morawetz, Josef A. Käs, and Jörg Schnauß

6 The Extracellular Matrix as a Target for Biophysical and Molecular Magnetic Resonance Imaging – Angela Ariza de Schellenberger, Judith Bergs, Ingolf Sack, and Matthias Taupitz

Part II Medical Imaging Technologies

7 Mathematical Methods in Medical Image Processing – Gitta Kutyniok, Jackie Ma, and Maximilian März

8 Acceleration Strategies for Data Sampling in MRI – Christoph Kolbitsch and Tobias Schaeffter

9 4D Flow MRI – Sebastian Schmitter and Susanne Schnell

10 CEST MRI – Martin Kunth and Leif Schröder

11 Innovative PET and SPECT Tracers – Ulrich Abram

12 Methods and Approaches in Ultrasound Elastography – Heiko Tzschätzsch

13 Photoacoustic Imaging: Principles and Applications – Jan Laufer

14 Fundamentals of X-Ray Computed Tomography: Acquisition and Reconstruction – Marc Dewey and Marc Kachelrieß

Part III Applications

15 Quantification of Myocardial Effective Transverse Relaxation Time with Magnetic Resonance at 7.0 Tesla for a Better Understanding of Myocardial (Patho)physiology – Till Huelnhagen, Teresa Serradas-Duarte, Fabian Hezel, Katharina Paul, and Thoralf Niendorf

16 Extracellular Matrix-Specific Molecular MR Imaging Probes for the Assessment of Aortic Aneurysms – Julia Brangsch, Carolin Reimann, and Marcus R. Makowski

17 Diffusion-Based MRI: Imaging Basics and Clinical Applications – Michael Scheel

18 Quantification of Functional Heterogeneities in Tumors by PET Imaging – Winfried Brenner, Florian Wedel, and Janet F. Eary

19 Tumor Characterization by Ultrasound Elastography and Contrast-Enhanced Ultrasound – Thomas Fischer, Anke Thomas, and Dirk-André Clevert

20 Sensitivity of Tissue Shear Stiffness to Pressure and Perfusion in Health and Disease – Jing Guo, Florian Dittmann, and Jürgen Braun

21 Radionuclide Imaging of Cerebral Blood Flow – Ralph Buchert

22 Cardiac Perfusion MRI – Amedeo Chiribiri

23 Myocardial Perfusion Assessment by 3D and 4D Computed Tomography – Marc Dewey and Marc Kachelrieß


23/09/2019 Steffen Lukas (AG Dewey) – Noise Reduction and Motion Elimination in Low-Dose 4D Myocardial Computed Tomography Perfusion (CTP): Preliminary Clinical Evaluation of the ASTRA4D Algorithm