Non-invasive detection of human cerebral population spikes in MEG and EEG

Festkolloquium der Abteilung 8
Medizinphysik und metrologische Informationstechnik

anlässlich der Verabschiedung von Herrn Dr. Martin Burghoff
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Freitag, 20. April 2018, 14.00 Uhr

Prof. Dr. med. Gabriel Curio

Klinik für Neurologie mit experimenteller Neurologie, Charité Berlin

Berlin Bernstein Center for Computational Neuroscience

Non-invasive detection of human cerebral population spikes in MEG and EEG

The capability to detect spikes defines a striking contrast between invasive (microscopic) and non-invasive (macroscopic) recordings. While the latter are dominated by summed postsynaptic potentials reflecting neuronal input, invasive electrodes can provide direct access also to the very output of neuronal computation – spikes. This micro/macro gap, however, has been narrowed gradually over the last years by combining special physiological paradigms with neurotechnological advances. Surveying this research agenda on spike-related high-frequency MEG/EEG the tripartite lecture will (i) address the basic neurophysics of near-field and far-field signals distinguishing slow from fast neuronal activities, (ii) elaborate on high-frequency (> 600 Hz) somatosensory evoked burst responses serving as a key paradigm to establish the feasibility of non-invasive spike-related recordings, and (iii) report on novel neurotechnology enabling high-resolution mappings of EEG activities even above 1 kHz which reflect non-invasive correlates of human neocortical multi-unit (‘population’) spike responses. Critically, if recording conditions provide optimal SNR, event detection of even single-trial (i.e., unaveraged) 600 Hz bursts becomes feasible, offering a unique perspective to study the immediate impact of cognitive processes on the generation of human cortical population spikes.

Ort:
Physikalisch-Technische Bundesanstalt – Institut Berlin
Hörsaal, HvH-Bau
Abbestraße 2-12, 10587 Berlin

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