- Mayer J, Wurster T, Schaeffter T, Landmesser U, Morguet A, Bigalke B, Hamm B, Brenner W, Makowski M, Kolbitsch C
Imaging coronary plaques using 3D motion-compensated [18F]NaF PET/MR
For publications (including conference contributions), please refer to BIOQIC in your acknowledgements:
“We gratefully acknowledge the financial support by the German Research Foundation (DFG), GRK2260 BIOQIC project 289347353″
Please send all accepted papers and conference presentations to: kristina-helena.pavicevic@charite.de
Sack I
Fortschr Röntgenstr 2017
ORIGINAL JOURNAL ARTICLES
2024
Time-harmonic optical flow with applications in elastography
Inverse Problems, 2024
Cardiac Elastography with External Vibration for Quantification of Diastolic Myocardial Stiffness
Journal of the American Society of Echocardiography, 2024
Magnetic resonance elastography in a nutshell: Tomographic imaging of soft tissue viscoelasticity for detecting and staging disease with a focus on inflammation
Prog Nucl Magn Reson Spectrosc., 2024
Multimodal assessment of brain stiffness variation in healthy subjects using magnetic resonance elastography and ultrasound time-harmonic elastography
Scientific Report, 2024
Pregnancy alters fatty acid metabolism, glucose regulation, and detoxification of the liver in synchrony with biomechanical property changes
Heliyon, 2024
In vivo characterization of brain tumor biomechanics: magnetic resonance elastography in intracranial B16 melanoma and GL261 glioma mouse models
Frontiers in Oncology, 2024
Rapid wideband characterization of viscoelastic material properties by Bessel function-based time harmonic ultrasound elastography (B-THE)
Journal of the Mechanical Behavior of Biomedical Materials, 2024
Cardiac Elastography with External Vibration for Quantification of Diastolic Myocardial Stiffness
Journal of the American Society of Echocardiography, 2024
Impact of training data composition on the generalizability of CNN aortic cross section segmentation in 4D Flow MRI
J Cardiovasc Magn Reson., 2024
Investigation of hepatic inflammation via viscoelasticity at low and high mechanical frequencies – A magnetic resonance elastography study
J Mech Behav Biomed Mater, 2024
The Networking Brain: How Extracellular Matrix, Cellular Networks, and Vasculature Shape the In Vivo Mechanical Properties of the Brain
Adv Sci (Weinh), 2024
Effects of oral contrast agent on the viscoelastic properties of the terminal ileum investigated using magnetic resonance elastography
Quant Imaging Med Surg., 2024
Learning carotid vessel wall segmentation in black-blood MRI using sparsely sampled cross-sections from 3D data
JMI, 2024
Cortical matrix remodeling as a hallmark of relapsing-remitting neuroinflammation in MR elastography and quantitative MRI
Acta Neuropathol., 2024
Explorative study using ultrasound time-harmonic elastography for stiffness-based quantification of skeletal muscle function
Zeitschrift für Medizinische Physik, 2024
Sensitivity of magnetic resonance elastography to extracellular matrix and cell motility in human prostate cancer cell line-derived xenograft models
Biomater Adv., 2024
On the relationship between viscoelasticity and water diffusion in soft biological tissues
Acta Biomater, 2024
Coronary Artery Calcium Score Predicts Major Adverse Cardiovascular Events in Stable Chest Pain
Radiology, 2024
Toward accurate and fast velocity quantification with 3D ultrashort TE phase-contrast imaging
Magnetic Resonance in Medicine, 2024
Roadmap on the use of artificial intelligence for imaging of vulnerable atherosclerotic plaque in coronary arteries
Nature Reviews Cardiology, 2024
2023
A simulation-based phantom model for generating synthetic mitral valve image data-application to MRI acquisition planning.
Int J Comput Assist Radiol Surg., 2023
Metallacages with 2,6‑dipicolinoylbis (N,N‑dialkylthioureas) as novel platforms in nuclear medicine for 68Ga, 177Lu and 198Au
EJNMMI Radiopharmacy and Chemistry, 2023
Shear Wave Elastography for Assessing Liver Stiffness in HCV-Infected Kidney Transplant Recipients after Direct-Acting Antiviral Treatment: A Comparative Study with Magnetic ResonanceElastography
Journal of Clinical Medicine, 2023
Motion‐corrected model‐based reconstruction for 2D myocardial T1 mapping
Magnetic Resonance in Medicine, 2023
Unified Bayesian network for uncertainty quantification of physiological parameters in dynamic contrast enhanced (DCE) MRI of the liver
Physics in Medicine & Biology, 2023
Rapid MR elastography of the liver for subsecond stiffness sampling.
Magnetic Resonance in Medicine, 2023
Stiffness pulsation of the human brain detected by non-invasive time-harmonic elastography.
Frontiers in Bioengineering and Biotechnology, 2023.
Characterization of renal fibrosis in rats with chronic kidney disease by in vivo tomoelastography
NMR in Biomedicine, 2023
Changes in Tissue Fluidity Predict Tumor Aggressiveness In Vivo
Advanced Science, 2023
The influence of static portal pressure on liver biophysical properties
Acta Biomaterialia, 2023
Data-efficient Bayesian learning for radial dynamic MR reconstruction
Med Phys., 2023
Clinical quantitative coronary artery stenosis and coronary atherosclerosis imaging: a Consensus Statement from the Quantitative Cardiovascular Imaging Study Group
Nat Rev Cardiol., 2023
MR Elastography in Cancer
Invest Radiol., 2023
Lazy Luna: Extendible software for multilevel reader comparison in cardiovascular magnetic resonance imaging
Comput Methods Programs Biomed., 2023
Multilevel comparison of deep learning models for function quantification in cardiovascular magnetic resonance: On the redundancy of architectural variations
Front Cardiovasc Med., 2023
Phenylimido Complexes of Rhenium: Fluorine Substituents Provide Protection, Reactivity and Solubility
Dalton Transactions, 2023
On the relationship between metabolic capacities and in vivo viscoelastic properties of the liver
Front. Bioeng. Biotechnol., 2023
Mechanical behavior of the hippocampus and corpus callosum: An attempt to reconcile ex vivo with in vivo and micro with macro properties
Journal of the Mechanical Behavior of Biomedical Materials, 2023
Pilot tone-based prospective correction of respiratory motion for free-breathing myocardial T1 mapping
Magnetic Resonance Materials in Physics, Biology and Medicine, 2023
2022
Summary and overview of the first ISMRM workshop on magnetic resonance elastography, August 25–26, 2022, Berlin, Germany
Magnetic Resonance in Medicine, 2022
The Chemistry of Phenylimidotechnetium(V) Complexes with Isocyanides: Steric and Electronic Factors
Molecules, 2022
Cerebral tomoelastography based on multifrequency MR elastography in two and three dimensions
Front. Bioeng. Biotechnol., 2022
3D model-based super-resolution motion-corrected cardiac T1 mapping
Phys. Med. Biol., 2022
Active multi-task learning with uncertainty weighted loss for coronary calcium scoring
Medical Physics, 2022
Cardio-respiratory motion-corrected 3D cardiac water-fat MRI using model-based image reconstruction
Magnetic Resonance in Medicine, 2022
Rapid estimation of 2D relative B1+-maps from localizers in the human heart at 7T using deep learning
Rhenium Complexes with p-Fluorophenylisocyanide
Mechanical properties of murine hippocampal subregions investigated by atomic force microscopy and in vivo magnetic resonance elastography
Sci Rep., 2022
Comparison of inversion methods in MR elastography: An open-access pipeline for processing multifrequency shear-wave data and demonstration in a phantom, human kidneys, and brain
Magnetic Resonance in Medicine, 2022
Valsalva Maneuver Decreases Liver and Spleen Stiffness Measured by Time-Harmonic Ultrasound Elastography
Front. Bioeng. Biotechnol., 2022
Mixed-Isocyanide Complexes of Technetium under Steric and Electronic Control
Inorganic Chemistry, 2022
Solid fraction determines stiffness and viscosity in decellularized pancreatic tissues
Biomaterials Advances, 2022
Insights into Imaging, 2022
Comparative effectiveness of initial computed tomography and invasive coronary angiography in women and men with stable chest pain and suspected coronary artery disease: multicentre randomised trial
BMJ, 2022
CT or Invasive Coronary Angiography in Stable Chest Pain
The New England Journal of Medicine, 2022
Introduction of Lazy Luna an automatic software-driven multilevel comparison of ventricular function quantification in cardiovascular magnetic resonance imaging
Scientific Reports, 2022
Calix[4]arene-Analogous Technetium Supramolecules
Inorg. Chem., 2022
Multiple motion encoding in phase-contrast MRI: A general theory and application to elastography imaging
Medical Image Analysis, 2022
Microscopic multifrequency MR elastography for mapping viscoelasticity in zebrafish
Magnetic Resonance in Medicine, 2022
Sexual Dimorphism in Extracellular Matrix Composition and Viscoelasticity of the Healthy and Inflamed Mouse Brain
Biology (Basel), 2022
Liquid-Liver Phantom: Mimicking the Viscoelastic Dispersion of Human Liver for Ultrasound- and MRI-Based Elastography
Invest Radiol., 2022
Calibration-free pTx of the human heart at 7T via 3D universal pulses
Magnetic Resonance in Medicine, 2022
Respiration induced B+1 changes and their impact on universal and tailored 3D kT-point parallel transmission pulses for 7T cardiac imaging
Magnetic Resonance in Medicine, 2022
Motion-compensated fat-water imaging for 3D cardiac MRI at ultra-high fields
Magnetic Resonance in Medicine, 2022
2021
Added Value of Tomoelastography for Characterization of Pancreatic Neuroendocrine Tumor Aggressiveness Based on Stiffness
Cancers (Basel), 2021
Detecting failure modes in image reconstructions with interval neural network uncertainty
Int J Comput Assist Radiol Surg. 2021 Dec;16(12):2089-2097
Tailored Magnetic Multicore Nanoparticles for Use as Blood Pool MPI Tracers
Nanomaterials, 2021
Detection of relevant extracardiac findings on coronary computed tomography angiography vs. invasive coronary angiography
Eur Radiol., 2022
An NMR relaxometry approach for quantitative investigation of the transchelation of gadolinium ions from GBCAs to a competing macromolecular chelator
Scientific Reports, 2021
Real-time multifrequency MR elastography of the human brain reveals rapid changes in viscoelasticity in response to the Valsalva maneuver
Frontiers in Bioengineering and Biotechnology, 2021
Real-time deformability cytometry detects leukocyte stiffening after gadolinium-based contrast agent exposure
Investigative Radiology, 2021
Respiratory motion correction for enhanced quantification of hepatic lesions in simultaneous PET and DCE-MR imaging
Physics and Engineering in Medicine, 2021
Ground-truth-free deep learning for artefacts reduction in 2D radial cardiac cine MRI using a synthetically generated dataset
Physics in Medicine & Biology, 2021
Tomoelastography for Longitudinal Monitoring of Viscoelasticity Changes in the Liver and in Renal Allografts after Direct-Acting Antiviral Treatment in 15 Kidney Transplant Recipients with Chronic HCV Infection
Journal of Clinical Medicine, 2021
Dynamic Contrast-Enhanced MRI of Prostate Lesions of Simultaneous [68Ga]Ga-PSMA-11 PET/MRI: Comparison between Intraprostatic Lesions and Correlation between Perfusion Parameters
Cancers, 2021
A Potential Renewed Use of Very Heavy Ions for Therapy: Neon Minibeam Radiation Therapy
Cancers, 2021
Imaging coronary plaques using 3D motion-compensated [18F]NaF PET/MR
European Journal of Nuclear Medicine and Molecular Imaging, 2021
Cerebral Ultrasound Time-Harmonic Elastography Reveals Softening of the Human Brain Due to Dehydration
Frontiers in Physiology, 2021
The Computational Complexity of Understanding Binary Classifier Decisions
Journal of Artificial Intelligence Research, 2021
Pilot tone–based motion correction for prospective respiratory compensated cardiac cine MRI
Magnetic Resonance in Medicine, 2021
Separation of fluid and solid shear wave fields and quantification of coupling density by magnetic resonance poroelastography
Magnetic Resonance in Medicine, 2021
Superviscous properties of the in vivo brain at large scales
Acta Biomaterialia, 2021
Three-dimensional static and dynamic parallel transmission of the human heart at 7 T
NMR in Biomedicine, 2021
3D Free-breathing multichannel absolute B+1 Mapping in the human body at 7T
Magnetic Resonance in Medicine, 2021
How histopathologic changes in pediatric nonalcoholic fatty liver diseases influence in vivo liver stiffness
Acta Biomater, 2021
Imaging coronary plaques using 3D motion-compensated [18F]NaF PET/MR
2020
Superviscous properties of the in vivo brain at large scales
Acta Biomaterialia, 2020
Three-dimensional static and dynamic parallel transmission of the human heart at 7 T
NMR in Biomedicine, 2020
3D Free-breathing multichannel absolute B+1 Mapping in the human body at 7T
Magn Reson Med, 2020
Adaptive sparsity level and dictionary size estimation for image reconstruction in accelerated 2D radial cine MRI
Med Phys, 2020
Lesion-to-background ratio threshold value of SUVmax of simultaneous [ 68 Ga]Ga-PSMA-11 PET/MRI imaging in patients with prostate cancer
Insights Imaging 2020
Changes in Liver Mechanical Properties and Water Diffusivity During Normal Pregnancy Are Driven by Cellular Hypertrophy
Front Physiol 2020
Correlation between Intraprostatic PSMA Uptake and MRI PI-RADS of [68Ga]Ga-PSMA-11 PET/MRI in Patients with Prostate Cancer: Comparison of PI-RADS Version 2.0 and PI-RADS Version 2.1
Cancers 2020
Reduction of breathing artifacts in multifrequency magnetic resonance elastography of the abdomen.
Magn Reson Med 2020
Microdistribution of Magnetic Resonance Imaging Contrast Agents in Atherosclerotic Plaques Determined by LA-ICP-MS and SR-μXRF Imaging
Mol Imaging Biol 2020
Clinical quantitative cardiac imaging for the assessment of myocardial ischaemia
Nature reviews cardiology 2020
Neural networks-based regularization for large-scale medical image reconstruction
Physics in Medicine & Biology 2020
4D flow imaging with UNFOLD in a reduced FOV.
Magn Reson Med. 2020
Cellular uptake of magnetic nanoparticles imaged and quantified by magnetic particle imaging.
Scientific Reports 2020
Ex vivo magnetic particle imaging of vascular inflammation in abdominal aortic aneurysm in a murine model
Scientific Reports 2020
Autocalibrated cardiac tissue phase mapping with multiband imaging and k-t acceleration
Magn Reson Med 2020
In vivo magnetic particle imaging: angiography of inferior vena cava and aorta in rats using newly developed multicore particles
Scientific Reports 2020
Link
Automatic prostate and prostate zones segmentation of magnetic resonance images using DenseNet-like U-net
Scientific Reports 2020
One Ligand, One Metal, Seven Oxidation States: Stable Technetium Complexes with the “Kläui Ligand”
Inorg Chem. 2020
Flexible numerical simulation framework for dynamic PET-MR data
Physics in Medicine & Biology 2020
In Vivo Quantification of Water Diffusion, Stiffness, and Tissue Fluidity in Benign Prostatic Hyperplasia and Prostate Cancer
Invest Radiol. 2020
Steady-State Multifrequency Magnetic Resonance Elastography of the Thoracic and Abdominal Human Aorta-Validation and Reference Values
Invest Radiol. 2020
Link
An analytical solution to the dispersion-by-inversion problem in magnetic resonance elastography
Magn Reson Med. 2020
Spatio-Temporal Deep Learning-Based Undersampling Artefact Reduction for 2D Radial Cine MRI With Limited Training Data
IEEE TMI 2020
Time-Resolved Response of Cerebral Stiffness to Hypercapnia in Humans
Ultrasound Med Biol 2020
SIRF: Synergistic Image Reconstruction Framework
Computer Physics Communications 2020
Ultrasound Time-Harmonic Elastography of the Pancreas: Reference Values and Clinical Feasibility
Invest Radiol 2020
MR Elastography-Based Assessment of Matrix Remodeling at Lesion Sites Associated Clinical Severity in a Model of Multiple Sclerosis
Front Neurol 2020
Separation of fluid and solid shear wave fields and quantification of coupling density by magnetic resonance poroelastography
Magn Reson Med 2020
Tomoelastography for Measurement of Tumor Volume Related to Tissue Stiffness in Pancreatic Ductal Adenocarcinomas
Invest Radiol 2020
Glycosaminoglycans as Novel Targets for in vivo Contrast-Enhanced Magnetic Resonance Imaging of Atherosclerosis
J Cardiol Cardiovasc Med 2020
2019
Quantification of Aortic Stiffness by Ultrasound Time-Harmonic Elastography: The Effect of Intravascular Pressure on Elasticity Measures in a Porcine Model
Invest Radiol 2019
MPI Phantom Study with A High-Performing Multicore Tracer Made by Coprecipitation
Nanomaterials 2019
Autocalibrated multiband CAIPIRINHA with through‐time encoding: proof of principle and application to cardiac tissue phase mapping
Magnetic resonance in medicine 2019
Evaluating Magnetic Resonance Spectroscopy as a Tool for Monitoring Therapeutic Response of Whole Brain Radiotherapy in a Mouse Model for Breast-to-Brain Metastasis
Front Oncol 2019
*Both authors contributed equally to this manuscript
How tissue fluidity influences brain tumor progression
Proceedings of the National Academy of Sciences 2019
Tomoelastography distinguishes non-invasively between benign and malignant liver lesions
Cancer Research 2019
Biomechanical properties of the hypoxic and dying brain quantified by magnetic resonance elastography
Real-time magnetic resonance elastography for viscoelasticity quantification in skeletal muscle during dynamic exercises
Magnetic Resonance in Medicine 2019
Fast myocardial T1 mapping using cardiac motion correction
Magn Reson Med 2019
Simultaneous high-resolution cardiac T1 mapping and cine imaging using model-based iterative image reconstruction
Magn Reson Med 2019
Viscoelasticity of striatal brain areas reflects variations in body mass index of lean to overweight male adults
Brain Imaging and Behavior 2019
Semi-automatic classification of prostate cancer on multi-parametric MR imaging using a multi-channel 3D convolutional neural network
European Radiology 2019
Brain maturation is associated with increasing tissue stiffness and decreasing tissue fluidity
Acta Biomater 2019
Tomoelastography for non-invasive detection and treatment monitoring in acute appendicitis
BMJ Case Rep 2019
3D nonrigid motion correction for quantitative assessment of hepatic lesions in DCE‐MRI
Magnetic Resonance in Medicine 2019
Ultrasound Time-Harmonic Elastography of the Aorta – Effect of Age and Hypertension on Aortic Stiffness
Investigative Radiology 2019
Spatio-Temporal Deep Learning-Based Undersampling Artefact Reduction for 2D Radial Cine MRI with Limited Data
IEEE Transactions on Medical Imaging 2019
US Time-Harmonic Elastography for the Early Detection of Glomerulonephritis
Radiology 2019
Multiparametric Quantitative MRI for the Detection of IgA Nephropathy Using Tomoelastography, DWI, and BOLD Imaging
Investigative Radiology 2019
The influence of body temperature on tissue stiffness, blood perfusion, and water diffusion in the mouse brain
Acta Biomaterialia 2019
A Rate-Distortion Framework for Explaining Neural Network Decisions
The Computational Complexity of Understanding Network Decisions
Cardiac-gated steady-state multifrequency magnetic resonance elastography of the brain: effect of cerebral arterial pulsation on brain viscoelasticity
Journal of Cerebral Blood Flow and Metabolism 2019
Tumor Control in RG2 Glioma-Bearing Rats: A Comparison Between Proton Minibeam Therapy and Standard Proton Therapy
Int J Radiat Oncol Biol Phys 2019
Noise reduction and motion elimination in low-dose 4D myocardial computed tomography perfusion (CTP): preliminary clinical evaluation of the ASTRA4D algorithm
European Radiology 2019
Non-invasive structure–function assessment of the liver by 2D time-harmonic elastography and the dynamic Liver MAximum capacity (LiMAx) test
Journal of Gastroenterology and Hepatology 2019
Sensitivity of multifrequency magnetic resonance elastography and diffusion-weighted imaging to cellular and stromal integrity of liver tissue
Journal of Biomechanics 2019
Increased Retention of Gadolinium in the Inflamed Brain After Repeated Administration of Gadopentetate Dimeglumine
Investigative Radiology 2019
Porous medium 3D flow simulation of contrast media washout in cardiac MRI reflects myocardial injury
Magn Reson Med 2019
4D flow imaging with 2D‐selective excitation
Magn Reson Med 2019
Collagen networks determine viscoelastic properties of connective tissues yet do not hinder diffusion of the aqueous solvent
Soft Matter 2019
2018
In vivo time-harmonic ultrasound elastography of the human brain detects acute cerebral stiffness changes induced by intracranial pressure variations
Sci Rep 2018
Fast tomoelastography of the mouse brain by multifrequency single‐shot MR elastography
Magn Reson Med 2018
Effect of X-ray minibeam radiation therapy on clonogenic survival of glioma cells
Clin Transl Rad Oncol 2018
Quantitative susceptibility mapping across two clinical field strengths: Contrast‐to‐noise ratio enhancement at 1.5T
J Magn Reson Imaging 2018
BOOKS
Quantification of Biophysical Parameters in Medical Imaging
Sack I, Schäffter T (editors)
Springer (ISBN-10: 3319659235) 2024, 2nd edition
The second edition of this book offers six new chapters covering the latest developments in quantitative medical imaging, including artificial intelligence, MRI mapping, sonography, elastography and cardiac CT. All the other existing chapters have been updated and expanded, many with new text and figures, to reflect the rapid translation and advancement of technology in this exciting area of biomedical research.
This updated edition presents fundamental knowledge on the imaging quantification of biophysical parameters for clinical diagnostic purposes. Clinical imaging scanners are considered by the authors as physical measurement systems capable of quantifying intrinsic parameters for the representation of the constitution and biophysical properties of tissues in vivo. In one respect, this approach fosters the development of new imaging methods for highly reproducible, system-independent, and quantitative biomarkers. These methods are greatly detailed in the book. Alternatively, this new edition equips the reader with a better understanding of how the physical properties of tissues interact with signal generation in medical imaging, opening up new insights into the complex and fascinating relationship between structure and function in living tissues.
This updated edition is of interest to all those who recognize the limitations of clinical diagnosis based primarily on visual inspection of images, and who wish to learn more about the diagnostic potential of quantitative, biophysically-based medical imaging markers, as well as the challenges posed by the scarcity of such markers for next-generation imaging technologies.
Contents
1 Introduction: Medical Imaging for the Quantitative Measurement of Biophysical Parameters
Part I Biological and Physical Fundamentals
2 Fundamentals of Transport in Living Tissues Quantified by Medical Imaging Technologies
3 Mathematical Modeling of Blood Flow in the Cardiovascular System
4 A Biphasic Poroelasticity Model for Soft Tissue
5 Physical Properties of Single Cells and Their Collective Behaviors
6 The Extracellular Matrix as a Target for Biophysical and Molecular Magnetic Resonance Imaging
Part II Medical Imaging Technologies
7 Mathematical Methods in Medical Image Processing
8 Acceleration Strategies for Data Sampling in Magnetic Resonance Imaging
9 Machine Learning for Quantitative Magnetic Resonance Image Reconstruction
10 4D Flow MRI
11 Quantitative MRI Using Multiparametric Mapping
12 CEST MRI
13 Innovative PET and SPECT Tracers
14 Methods and Approaches in Ultrasound Elastography
15 Photoacoustic Imaging: Principles and Applications
16 Fundamentals of X-Ray Computed Tomography: Acquisition and Reconstruction
Part III Applications
17 Quantification of Myocardial Effective Transverse Relaxation Time with Magnetic Resonance at 7.0 Tesla for a Better Understanding of Myocardial (Patho)physiology
18 Extracellular Matrix–Specific Molecular MR Imaging Probes for the Assessment of Aortic Aneurysms
19 Diffusion-Based MRI-Imaging Basics and Clinical Applications
20 Tumor Characterization by Sonoelastography and Contrast-Enhanced Ultrasound
21 Quantitative Bone Ultrasound
22 Mechanical Imaging of the Aorta
23 Sensitivity of Tissue Shear Stiffness to Pressure and Perfusion in Health and Disease
24 Radionuclide Imaging of Regional Cerebral Blood Flow
25 Cardiac Perfusion MRI
26 Myocardial Perfusion Assessment by 3D and 4D Computed Tomography
27 Roadmap on the Use of Artificial Intelligence for Imaging of Vulnerable Atherosclerotic Plaque in Coronary Arteries
28 Clinical Quantitative Coronary Artery Stenosis and Coronary Atherosclerosis Imaging: A Consensus Statement from the Quantitative Cardiovascular Imaging Study Group
BIOQIC book “Quantification of Biophysical Parameters in Medical Imaging”
The eBook can be downloaded here and is suitable for most mobile reading devices.
The book, edited by Ingolf Sack and Tobias Schaeffter, provides a selection of essential knowledge on the image-based quantification of biophysical parameters for the purpose of clinical diagnosis. The authors regard clinical imaging scanners as physical measurement systems capable of quantifying intrinsic parameters for depiction of the constitution and biophysical properties of in vivo tissue. On the one hand, this approach supports the development of new methods of imaging highly reproducible, system-independent, and quantitative biomarkers, and these methods receive detailed attention in the book. On the other hand, the reader will also gain a deeper understanding of how physical tissue properties interact with the generation of signals in medical imaging, opening new windows on the intricate and fascinating relationship between the structure and function of living tissues. The book will be of interest to all who recognize the limitations of basing clinical diagnosis primarily on visual inspection of images and who wish to learn more about the diagnostic potential of quantitative and biophysics-based medical imaging markers and the challenges that the paucity of such markers poses for next-generation imaging technologies.
CONTENTS:
1 Introduction: Medical Imaging for the Quantitative Measurement of Biophysical Parameters – Ingolf Sack and Tobias Schaeffter
Part I Biological and Physical Fundamentals
2 The Fundamentals of Transport in Living Tissues Quantified by Medical Imaging Technologies – Sebastian Hirsch, Tobias Schaeffter, and Ingolf Sack
3 Mathematical Modeling of Blood Flow in the Cardiovascular System – Alfonso Caiazzo and Irene E. Vignon-Clementel
4 A Biphasic Poroelasticity Model for Soft Tissue – Sebastian Hirsch
5 Physical Properties of Single Cells and Collective Behavior – Hans Kubitschke, Erik W. Morawetz, Josef A. Käs, and Jörg Schnauß
6 The Extracellular Matrix as a Target for Biophysical and Molecular Magnetic Resonance Imaging – Angela Ariza de Schellenberger, Judith Bergs, Ingolf Sack, and Matthias Taupitz
Part II Medical Imaging Technologies
7 Mathematical Methods in Medical Image Processing – Gitta Kutyniok, Jackie Ma, and Maximilian März
8 Acceleration Strategies for Data Sampling in MRI – Christoph Kolbitsch and Tobias Schaeffter
9 4D Flow MRI – Sebastian Schmitter and Susanne Schnell
10 CEST MRI – Martin Kunth and Leif Schröder
11 Innovative PET and SPECT Tracers – Ulrich Abram
12 Methods and Approaches in Ultrasound Elastography – Heiko Tzschätzsch
13 Photoacoustic Imaging: Principles and Applications – Jan Laufer
14 Fundamentals of X-Ray Computed Tomography: Acquisition and Reconstruction – Marc Dewey and Marc Kachelrieß
Part III Applications
15 Quantification of Myocardial Effective Transverse Relaxation Time with Magnetic Resonance at 7.0 Tesla for a Better Understanding of Myocardial (Patho)physiology – Till Huelnhagen, Teresa Serradas-Duarte, Fabian Hezel, Katharina Paul, and Thoralf Niendorf
16 Extracellular Matrix-Specific Molecular MR Imaging Probes for the Assessment of Aortic Aneurysms – Julia Brangsch, Carolin Reimann, and Marcus R. Makowski
17 Diffusion-Based MRI: Imaging Basics and Clinical Applications – Michael Scheel
18 Quantification of Functional Heterogeneities in Tumors by PET Imaging – Winfried Brenner, Florian Wedel, and Janet F. Eary
19 Tumor Characterization by Ultrasound Elastography and Contrast-Enhanced Ultrasound – Thomas Fischer, Anke Thomas, and Dirk-André Clevert
20 Sensitivity of Tissue Shear Stiffness to Pressure and Perfusion in Health and Disease – Jing Guo, Florian Dittmann, and Jürgen Braun
21 Radionuclide Imaging of Cerebral Blood Flow – Ralph Buchert
22 Cardiac Perfusion MRI – Amedeo Chiribiri
23 Myocardial Perfusion Assessment by 3D and 4D Computed Tomography – Marc Dewey and Marc Kachelrieß
DISSERTATIONS
23/09/2019 Steffen Lukas (AG Dewey) – Noise Reduction and Motion Elimination in Low-Dose 4D Myocardial Computed Tomography Perfusion (CTP): Preliminary Clinical Evaluation of the ASTRA4D Algorithm