We would like to announce the seminar by Dominique Chapelle, WIAS seminar series in Quantitative Biomedizin, on September 18th!

Dominique Chapelle (Inria Saclay Ile-de-France Research Center)
Biomechanical modeling of the heart, and cardiovascular system – From sarcomeres to organ / system, with experimental assessments and patient-specific clinical validations

Cardiac contraction originates at a subcellular – molecular, indeed – scale, within specific components of the cardiomyocytes (i.e. cardiac cells) called sarcomeres. This contractile behaviour then needs to be integrated at the organ level, namely, with a specific structure and shape. Furthermore, this organ crucially interacts with other physiological systems, the first of which being blood circulation via the cardiac function itself, and also the nervous system that controls the heart via various regulation mechanisms, and these interactions must be adequately represented in order to obtain accurate and predictive model simulations. This presentation will provide an overview of the recent advances on cardiac modeling achieved in the M3DISIM group, with a particular focus on the key multiscale, multi-physics and integrated system modeling aspects that need to be addressed, with many associated challenges pertaining to numerical methods, model validation, and inverse problems, in particular.


For info see: http://www.wias-berlin.de/seminars/QuantBio/

Place: Weierstrass-Institute for Applied Analysis and Stochastics, Mohrenstraße 39, 10117 Berlin, Erhard Schmidt Lecture Room (ESH)
Time: Monday September 18t, 2:00PM – 3:00PM
Organizers: Alfonso Caiazzo, Michael Hintermüller, Karsten Tabelow, Barbara Wagner